Saturday 12.10.2013

Scientific Session Satellite Symposium Main Program Hematology Educational Workshop
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Session details 08:30–13:45
Hematology Educational

Hematology Educational

Room:Pipin II (Dorint Hotel)
Session details 10:00–11:30
Workshop 1 (Parallel Sessions)

Prognostic and biomarkers – tissue and serum / plasma

Room:Pipin II (Dorint Hotel)
  • The immunomodulatory and angiogenic protein Galectin 1 is a circulating biomarker in Hodgkin Lymphoma

  • Plasma TARC as a treatment response marker and prognostic tissue biomarkers in classical Hodgkin Lymphoma

  • Prognostic biomarkers from gene expression pro ling in formalin- xed para n-embedded biopsies

  • Flow cytometry studies of lymphocyte predominant cells from nodular Lymphocyte Predominant Hodgkin Lymphoma

  • Identication of CD8 ‘follicularcytotoxic’ cells in tumor infiltrating T cells from classical Hodgkin Lymphoma

Session details 10:00–11:30
Workshop 2 (Parallel Sessions)

Closed workshop for pediatric groups

Room:Sandkaul (Dorint Hotel)
  • Overview of international harmonization of staging and response criteria in pediatric Hodgkin Lymphoma – summary of results thus far

  • Highlights and controversies found between existing major pediatric groups

  • Discussion

Session details 12:00–13:30
Workshop 3 (Parallel Sessions)

GHSG Workshop

Room:Martin & Augustin (Dorint Hotel)
Session details 12:00–13:30
Workshop 4 (Parallel Sessions)

Radiotherapy of Hodgkin Lymphoma in 2013

Room:Pipin II (Dorint Hotel)
  • New concepts of eld and dose: Implications for disease control and long-term outcome

  • The role of radiotherapy in early stage and the relevance of PET response

  • Is radiotherapy still relevant for patients with advanced stage disease and in salvage of chemotherapy failures?

Session details 12:00–13:30
Workshop 5 (Parallel Sessions)

Challenges in the development of new drugs in HL

Room:Severin (Dorint Hotel)
  • Progress on new drug development in Hodgkin Lymphoma

  • Clinical trials design, response assessment, and trial end points

  • Challenges of translation of abundant new data into clinical trials in rare diseases

  • Challenges of preclinical models

Session details 14:00–15:30
Workshop 6 (Parallel Sessions)

New technologies for improving the therapeutic ratio of RT in HL

Room:Pipin II (Dorint Hotel)
Session details 14:00–15:30
Workshop 7 (Parallel Sessions)

PET

Room:Pipin I (Dorint Hotel)
  • The new NCCN guidelines and the role of PET / CT

  • Imaging and PET / CT recommendations for the revised staging and response criteria

  • Metabolic tumor volume and other new concepts

  • qPET – a quantitative approach to assess response in interim FDG-PET scans in lymphoma

Session details 14:00–15:30
Workshop 8 (Parallel Sessions)

Somatic aberrations, epigenetic mechanisms and deregulated gene expression

Room:Severin (Dorint Hotel)
  • Novel and recurrent coding sequence mutations in microdissected Hodgkin-/ Reed- Sternberg cells

  • No chance for a comeback? The multiple ways to block the B-cell phenotype in Hodgkin Lymphoma

  • New insights into the transcription factor network of Hodgkin-/ Reed-Sternberg cells

  • Transcriptome analysis of Hodgkin and Reed-Sternberg cells enriched from Hodgkin Lymphoma biopsies: an approach to virus discovery

  • Downregulation of FOXO1 prevents induction of the tumor suppressor PRDM1 in cHL

Session details 16:00–17:30
Workshop 9 (Parallel Sessions)

Integrating PET into the management of early stage HL

Room:Pipin I (Dorint Hotel)
  • Introduction

  • RAPID trial: Update and lessons in standardized interpretation of PET

  • BCCA experience: Population-based PET guided treatment

  • Challenges applying PET for early stage disease

  • What did EORTC H10 teach us?

  • Formulation of conclusions and identi cation of important outstanding questions

Session details 16:00–17:30
Workshop 10 (Parallel Sessions)

International Guidelines on Follow-up and Survivorship

Room:Martin & Augustin (Dorint Hotel)
  • Some “philosophical” introductoryremarkson the need and pitfalls of long-term follow-up

  • The ASCO and the Dutch guidelines

  • Minimizing treatment and its consequences for long term toxicity and follow-up

  • Reducing RT to involved node principle and its consequences for long-term toxicity and follow-up

  • General discussion

Session details 16:00–17:30
Workshop 11 (Parallel Sessions)

Genetic predisposition – HLA, GWAS, secondary malignancies, prognostic

Room:Severin (Dorint Hotel)
  • Familial risks and germline genetics of Hodgkin Lymphoma

  • HLA locus and risk of Hodgkin Lymphoma

  • Multiple neoplasias a er Hodgkin Lymphoma; incidence and risk factors

  • Genetic defects of T-cell function predisposing for EBV-associated lymphoproliferation and Hodgkin Lymphoma

  • General discussion

Session details 18:00–19:00
Workshop 12

Targeted Therapy: The Future in the Treatment of Malignant Lymphoma

Room:Pipin I (Dorint Hotel)
  • New approaches in the treatment of mantle cell and other Non Hodgkin Lymphoma

  • New horizons in the treatment o CLL

Sunday 13.10.2013

Scientific Session Satellite Symposium Main Program Hematology Educational Workshop
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Session details 07:30–08:30
Satellite Symposium

Novel Methodology to aid in the Diagnosis of Difficult Hodgkin Lymphoma Cases

Room:Großer Saal
  • Introduction and Perspective

  • Novel methodology to aid in the diagnosis of di cult lymphoma cases

  • Case Series Presentation using MultiOmyx Methodology

  • Questions & Answers

Session details 08:30–10:00
Scientific Session 1

Interactive Case Discussions

Room:Großer Saal
Session details 10:30–12:00
Scientific Session 2

Pathways

Room:Großer Saal
  • JAK / STAT

  • Non-coding RNA and tumor cell survival

  • CSF1 and CSF1R

  • Integrated genomic analysis of ow sorted Hodgkin and Reed-Sternberg cell in primary classical Hodgkin Lymphoma

  • TCF3 / E2A (19p13.3) is a novel Hodgkin Lymphoma susceptibility locus; a meta-GWAS study from the InterLymph Hodgkin Lymphoma consortium

  • Hodgkin-Reed-Sternberg cells in classical Hodgkin Lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity

Session details 12:15–13:45
Satellite Symposium

Lenalidomide in Lymphoma – Latest Update on Clinical Data

Room:Großer Saal
Session details 14:00–15:15
Satellite Symposium

New Insights in the Treatment and Management of Lymphoid Malignancies

Room:Großer Saal
  • New Aspects on Dose Density in Malignant Lymphoma

  • The impact of hematological toxicity in Hodgkin Lymphoma

  • Bispeci c CD19 antibodies – a new treatment principle for management of relapsed / refractory ALL and NHL

Session details 16:00–17:30
Satellite Symposium

Relapsed/Refractory Hodgkin Lymphoma: Exploring Targeted Therapeutic Options

Room:Großer Saal
  • Welcome and Introduction

  • The challenge of relapsed Hodgkin Lymphoma in the era of contemporary therapy

  • Q&A

  • Defining the ideal target in Hodgkin Lymphoma

  • Q&A

  • Targeting CD30 with monoclonal antibody- based constructs

  • Q&A

  • Current success and future opportunities with targeted therapy in Hodgkin Lymphoma

  • Q&A

  • Closing comments

Session details 18:00–20:00
Main Program

Opening Ceremony

Room:Großer Saal
  • Bonadonna Lecture: The Hodgkin puzzle: Are we getting close?

  • Awards Ceremony

Session details 20:00
Main Program

Get Together

Room:Weinkeller

Monday 14.10.2013

Scientific Session Satellite Symposium Main Program Hematology Educational Workshop
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Session details 07:30–08:30
Satellite Symposium

Beyond the revolution of MabThera

Room:Großer Saal
Session details 08:30–10:00
Scientific Session 3

Biology and Microenvironment

Room:Großer Saal
  • Microenvironment in Hodgkin Lymphoma

  • Molecular pathogenesis of Hodgkin Lymphoma

  • Deregulation of di erentiation in pathogenesis of cHL

  • Plasma microRNA are disease response biomarkers in classical Hodgkin Lymphoma

  • CD57+ T cells in nodular lymphocyte predominant Hodgkin Lymphoma are T-follicular helper cells

  • Analysis of myeloid suppressor marker Arginase identi es CD68+ / Arginase+ myeloid / monocytic subsets and exerts stronger prognostic in uence than macrophage quanti cation in Classical Hodgkin Lymphoma

Session details 10:30–12:00
Scientific Session 4

Early Stages

Room:Großer Saal
  • Update on the NCRI RAPID trial

  • An update on the EORTC / LYSA / FIL H10 trial

  • WS report and further optimization in early stage Hodgkin Lymphoma

  • Impact of bleomycin and dacarbazine within the ABVD regimen in the treatment of early-stage favorable Hodgkin Lymphoma: Final results of the GHSG HD13 trial

  • De nition of bulky disease in early stage Hodgkin Lymphoma in computed tomography era: Prognostic signi cance of measurements in the coronal and transverse planes

  • Brentuximab vedotin plus AVD as initial therapy of non-bulky limited stage classical Hodgkin Lymphoma: Interim analysis of an ongoing phase II trial

Session details 12:15–13:45
Satellite Symposium

NHL and G-CSF – Focus on optimising the results

Room:Großer Saal
Session details 14:00–15:30
Scientific Session 5

Hodgkin lymphoma in older patients

Room:Großer Saal
  • Epidemiology and biology

  • First line treatment

  • Relapsed / refractory Hodgkin Lymphoma in older patients

  • GHSH phase I / II trial of AVD-Rev (adriamycin, vinblastin, dacarbacine and lenalidomide) for older Hodgkin Lymphoma patients

  • Sequential brentuximab vedotin (BV) and adriamycin, vinblastine, and dacarbazine (AVD) for older patients with untreated Hodgkin Lymphoma (HL): Preliminary toxicity ndings from a phase II window study

  • Treatment outcome in 111 elderly patients with Hodgkin Lymphoma: a retrospective analysis

Session details 15:45–17:30
Scientific Session 6

PET and prediction

Room:Großer Saal
  • PET for early response prediction

  • PET review in GHSG trials

  • PETinrelapsedorrefractoryHodgkinLymphoma

  • Response-adapted therapy of stage III-IV Hodgkin lymphoma based on interim FDG-PET imaging: early results of US intergroup S0816

  • Very early response as measured by (18F)- uorodeoxyglucose-positron emission tomography (FDG-PET) a er one cycle of chemotherapy in newly diagnosed pediatric / adolescent low risk Hodgkin Lymphoma (HL)

  • Tailored therapy in Hodgkin Lymphoma, based on prede ned risk factors and early interim PET / CT, Israeli H2 protocol: Preliminary report on 317 patients

Session details 17:45–19:15
Satellite Symposium

Defining Therapeutic Targets in T-Cell Lymphoma

Room:Großer Saal
  • Welcome and Introduction

  • Traditional Approaches to T-cell Lymphoma

  • Q&A

  • Transition with targeted agents in T-cell Lymphoma

  • Q&A

  • Targeting CD30 in T-cell Lymphoma

  • Q&A

  • Challenging the experts: An interactive panel discussion

  • Adjourn

Tuesday 15.10.2013

Scientific Session Satellite Symposium Main Program Hematology Educational Workshop
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Session details 07:30–09:00
Workshop 13

Beyond the International Harmonization Criteria – New challenges in the application of imaging techniques for staging and response

Room:Großer Saal
  • Practical experience in the application of the International Harmonization Criteria – as viewed by a medical oncologist

  • Anatomic imaging challenges of the International Harmonization Criteria

  • Nuclear medicine aspects of the International Harmonization Criteria, as they apply to pediatrics

  • Overview of the challenges encountered by the Pediatric International Harmonization Criteria Workshop

  • Discussion

Session details 09:00–10:30
Scientific Session 7

Survivorship

Room:Großer Saal
Session details 11:00–12:30
Scientific Session 8

Advanced Stages

Room:Großer Saal
  • Risk-adapted therapy in advanced stage Hodgkin Lymphoma: An Update

  • Can we improve ABVD?

  • Can we improve BEACOPP?

  • Impact of dose reductions of bleomycin and vincristine in patients with advanced Hodgkin Lymphoma treated with BEACOPP polychemotherapy: A comprehensive analysis of the German Hodgkin Study Group (GHSG) HD12 and HD15 trials

  • Standard ABVD vs. escalated BEACOPP in stage III – IV low risk Hodgkin Lymphoma (IPS 0-2): the Lymphoma Study Association (LYSA) H34 trial

  • Response rates and toxicity of response-adapted therapy in advanced Hodgkin Lymphoma: initial results from the international RATHL study

Session details 12:45–14:15
Satellite Symposium

Update on Infectious Diseases in Hematology Patients

Room:Großer Saal
  • Introduction

  • Clinical infectious challenges in patients with Hodgkin Lymphoma

  • Present and upcoming vaccines for the immunocomprised host

  • Focussing on unmet medical needs in abdominal infections

  • Discussion and Summary

Session details 13:45–14:15
Main Program

Poster Walk

Room:Kleiner Saal
Session details 14:30–16:00
Scientific Session 9

Relapsed

Room:Großer Saal
  • What’s new in relapsed Hodgkin Lymphoma?

  • Debate: Is there still a role for allogeneic TX in Hodgkin Lymphoma?

  • Phase 2 study everolimus for relapsed / refractory classical Hodgkin Lymphoma (cHL)

  • Outcome of patients treated with autologous stem-cell transplantation for rst relapsed or refractory Hodgkin Lymphoma: A long-term analysis of the prospective LYSA / SFGM-TC H96 trial

  • PET adapted sequential salvage therapy with brentuximab vedotin and augmented ICE for transplant eligible patients with relapsed and refractory Hodgkin Lymphoma

Session details 16:15–18:00
Scientific Session 10

Milestones in Hodgkin Lymphoma

Room:Großer Saal
Session details 20:00
Main Program

Closing Remakrs

Room:Großer Saal

Basement

Allocations

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Ground Floor

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First Floor

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  • Room details Großer Saal

    Main Program, Satellite Symposia, Workshop

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Dorint Hotel: Ground Level

Allocations

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Dorint Hotel: First Floor

Allocations

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Exhibition

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Acknowledgements

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